tag:blogger.com,1999:blog-1063416407663011642.post2996450029321487967..comments2024-03-12T14:30:18.196-07:00Comments on End Eczema: Irwin McLean's filaggrin readthrough drug could be revolutionarySpanish Keyhttp://www.blogger.com/profile/01839125247451906949noreply@blogger.comBlogger17125tag:blogger.com,1999:blog-1063416407663011642.post-42333141742027491712022-07-06T03:26:01.569-07:002022-07-06T03:26:01.569-07:00Very good blog about eczema. If any query then you...Very good blog about eczema. If any query then you can also visit our <a href="https://www.sriramakrishnahospital.com/minor-department/dermatology/" rel="nofollow">best dermatologist</a>.<br />Sonakshihttps://www.sriramakrishnahospital.com/minor-department/dermatology/noreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-3422896431217924972022-07-01T03:18:31.840-07:002022-07-01T03:18:31.840-07:00Very nice blog that you have shared
Check our our...Very nice blog that you have shared<br /><br />Check our our blog to learn more about <a href="https://skindiseasehospital.org/can-eczema-on-the-face-caused-by-environmental-factors/" rel="nofollow">different types of eczema on face</a>.Skin Disease Hospitalhttps://www.blogger.com/profile/14451029119462429423noreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-36756041588471453732022-07-01T03:17:14.296-07:002022-07-01T03:17:14.296-07:00Nice post!Nice post!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-38065387855997249952019-07-16T19:31:32.881-07:002019-07-16T19:31:32.881-07:00Hiv disease for the last 3 years and had pain hard...Hiv disease for the last 3 years and had pain hard to eat and cough are nightmares,especially the first year At this stage, the immune system is severely weakened, and the risk of contracting opportunistic infections is much greater. However, not everyone with HIV will go on to develop AIDS. The earlier you receive treatment, the better your outcome will be.I started taking ARV to avoid early death but I had faith in God that i would be healed someday.As a Hiv patent we are advise to be taking antiretroviral treatments to reduce our chance of transmitting the virus to others , few weeks ago i came on search on the internet if i could get any information on Hiv treatment with herbal medicine, on my search i saw a testimony of someone who has been healed from Hiv her name was Achima Abelard and other Herpes Virus patent Tasha Moore also giving testimony about this same man,Called Dr Itua Herbal Center.I was moved by the testimony and i contacted him by his Email.drituaherbalcenter@gmail.com OR info@drituaherbalcenter.com. We chatted and he send me a bottle of herbal medicine I drank it as he instructed me to.After drinking it he ask me to go for a test that how i ended my suffering life of Hiv patent,I'm cured and free of Arv Pills.I'm forever grateful to him Drituaherbalcenter.Here his contact Number +2348149277967...He assure me he can cure the following disease..Hiv,Cancer,Herpes Virus,Hpv,Pile,Weak Erection,Lyme Disease,Epilepsy,Glaucoma.,Brain Tumor,psoriasis, Cataracts,Macular degeneration,Cardiovascular disease,Chronic Diarrhea,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,<br />Dementia. ,Bladder Cancer,Autism,Colorectal Cancer,Breast Cancer,Kidney Cancer,Leukemia,Lung Cancer,Tay tach disease,Non Hodgkin Lymphoma,Skin Cancer,Lupus,Uterine Cancer,Prostate Cancer, Seizures, fibromyalgia ,ALS,Hepatitis,Copd,Parkinson disease.Genetic disease,Fibrodysplasia disease,Fibrodysplasia Ossificans Progressiva,Fluoroquinolone Toxicity Syndrome,Stroke,Hpv,Weak Erection,Liver/Kidney Inflammatory,Men/Woman infertility, bowel disease ,Huntington's disease ,Diabetes,Fibroid.Tara Omarhttps://www.blogger.com/profile/18070904996225573447noreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-22855376238062049322018-05-08T02:24:47.849-07:002018-05-08T02:24:47.849-07:00this is very informative. this tips will help in t...this is very informative. this tips will help in the treatment.<br /><a href="http://www.drhealthclinic.com/" rel="nofollow"><b> skin care clinic in Bangalore </b></a> Dr. Health Clinichttps://www.blogger.com/profile/03952546613364150335noreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-31802111882179011752016-12-28T10:08:10.923-08:002016-12-28T10:08:10.923-08:00This Foderma serum has been life changing for my d...This Foderma serum has been life changing for my daughter. From kid she started getting eczema. It was heartbreaking. She would scratch her skin to the point of bleeding at night at 10 years old. We tried every prescription- I hated putting steroid cream on my daughter! This lotion cleared up her eczema completely.Vidaa Goldsteinnoreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-40124384721523134132016-09-19T04:41:50.541-07:002016-09-19T04:41:50.541-07:00Love the Foderma. It has cleared up a continuing p...Love the Foderma. It has cleared up a continuing problem with my hands. It took about a month, but started to help within a few days. Use it every day to keep it under control. Have had the problem since I was ten, off and on, and it was horrible when I started using the Foderma. Cracked and bleeding fingers. Will always keep it on hand. Thanks for the great product!!Garcianoreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-69542154343246924072015-11-01T15:01:24.611-08:002015-11-01T15:01:24.611-08:00Hello everyone! I just wanted to share an experien...Hello everyone! I just wanted to share an experience I had with my toddler's eczema outbreaks. A few weeks ago, my baby was having terrible breakouts and it was the worse I have ever seen it. His entire little body was covered with redhot circles. Even his neck was breaking out, something I had never seen before. He was scratching like crazy as you can only imagine. I tried everything and sadly nothing was working. The doctor recommended the lotion Eucerin for his eczema, but I have to say, it was no different than any other lotion. I didn't help at all. I came across a lotion that a friend told me about. It is made with only the best natural ingredients out there today. I applied it all over my baby's body and put him down for the night. In the morning, when he woke up, I changed his diaper like I normally do. That's when I saw that his skin had begun the healing process. He was no longer itching and his red open sores we're starting to dry up. This lotion was a miracle that I was praying for days. <br /><br />The best part of all is that it is made with non toxic natural ingredients, it’s way cheaper than Eucerin or any other lotion you can buy at the store, and it moisturizes 8 times better than anything out there. So, I can afford to use this lotion as an everyday moisturizer so that my little one never has to go thru that at all. <br /><br />If you want to hear more about this all natural lotion that worked like a miracle please e-mail me and I can tell you all about it. I guarantee that you will never buy another lotion in your life, because I know for sure I wont. I know that this lotion will help you just as it helped my baby heal and stop scratching for good. It is a sold company that has been around for over 30 years and has excellent reviews. <br /><br />My e-mail address is jasmin727@hotmail.com <br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-40126798385958783692015-09-05T07:10:45.931-07:002015-09-05T07:10:45.931-07:00the power you have as a parent of a public-school ...the power you have as a parent of a public-school kid depends on how much time you're putting into raising money for the school. <a href="http://homeremediesforeczema.org/" rel="nofollow">http://homeremediesforeczema.org/</a><br />jadehttps://www.blogger.com/profile/13835847777966515522noreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-32456213491087767992013-07-11T16:36:31.970-07:002013-07-11T16:36:31.970-07:00Email me at spanishkey71@gmail.com. We should intr...Email me at spanishkey71@gmail.com. We should introduce ourselves.Spanish Keyhttps://www.blogger.com/profile/01839125247451906949noreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-79565644505095985682013-07-11T16:35:47.342-07:002013-07-11T16:35:47.342-07:00I dunno. If I were a competing scientist at big ph...I dunno. If I were a competing scientist at big pharma, I might find that wording vulnerable. I'd think it would be best to be as specific as possible. I mean, look at the detail they go into in the individual claims.Spanish Keyhttps://www.blogger.com/profile/01839125247451906949noreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-76903710793923118172013-07-11T14:49:40.082-07:002013-07-11T14:49:40.082-07:00Don´t you think AD fits under the atopy umbrella?Don´t you think AD fits under the atopy umbrella?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-49261516143577476062013-07-11T14:48:10.544-07:002013-07-11T14:48:10.544-07:00Agreed. I bet there has been a lot of "move o...Agreed. I bet there has been a lot of "move one step back". But I believe/hope that they have done their work properly. AD/IV/atopy patients are one h*ll of a powerful group, and skin disease patients have always been "itching" for a cure. And this discovery of the first genetic predisposing factor for AD has indeed triggered a lot of media interest. Thus, I don´t think they would move in to trials in humans if they not were confident that their compound(s) might work. The media coverage has been too comprehensive, the patient group is "too big to disappoint", (if you catch my drift), and the related diseases are not life threatening, so I don't think that time ha been an issue. In my mind, they are working to develop a high quality product that not necessarily has to enter market "tomorrow". Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-57888951137504592422013-07-11T13:48:17.745-07:002013-07-11T13:48:17.745-07:00You are right on that.
That graphic you link to i...You are right on that.<br /><br />That graphic you link to is very informative. It gives a good idea of how much McLean's people have already achieved.<br /><br />I suspect that the actual process of drug discovery is a little more complicated though, with arrows looping back around. Spanish Keyhttps://www.blogger.com/profile/01839125247451906949noreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-80354843208566869652013-07-11T13:44:19.801-07:002013-07-11T13:44:19.801-07:00You would think that McLean would have filed anoth...You would think that McLean would have filed another patent explicitly for this technique in AD. He appears not to have.<br /><br />However, if you search patent APPLICATIONS (as opposed to patents granted) you find <a href="http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=%2Fnetahtml%2FPTO%2Fsearch-adv.html&r=2&p=1&f=G&l=50&d=PG01&S1=%28irwin+AND+mclean%29.IN.&OS=in/%28irwin+and+mclean%29&RS=IN/%28irwin+AND+mclean%29" rel="nofollow">another listing</a> which covers FLG mutations as diagnostics for infants developing AD--and also gene therapy for FLG mutation. IMO it's pretty bold of him to pack those two concepts into a single patent!Spanish Keyhttps://www.blogger.com/profile/01839125247451906949noreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-46745434848049214662013-07-11T12:08:01.979-07:002013-07-11T12:08:01.979-07:00And btw, I wouldn´t say that the FDA graphic shows...And btw, I wouldn´t say that the FDA graphic shows the drug discovery process. In my (and FDA´s) opinion, it shows the drug approval process. Drug discovery is basically done in step one, and maybe step two, in the FDA graphic. Of course, the graphic illustrates your point brilliantly, and the clinical trials and the approval processes are extremely time consuming,<br />but I would say that this figure illustrates drug discovery process itself better: (check out <br />what´s the last step!)<br />http://www.celgene.com/research/drug-discovery-and-development.aspx<br /><br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1063416407663011642.post-52029052720281444362013-07-11T11:37:02.661-07:002013-07-11T11:37:02.661-07:00Well, hat tip back to you.
I´ve been thinking a l...Well, hat tip back to you.<br /><br />I´ve been thinking a little bit of the fact that they don´t mention the word "dermatitis" or "eczema" in the patent application. <br /><br />When they were searching for mutations in filaggrin, they studied individuals with Ichthyosis Vulgaris, not AD. I bet they wrote the claims before they were able to prove the high prevalence of FLG mutation in AD. At that time, the inside-out hypothesis was the dominating one in AD research, and this research changed that paradigm. Now the outside-in hypothesis is dominating. I think they found that a potential cure for IV was reason "good enough" to file the patent application, and wanted to do before anybody else did so. Mind you, the FLG/IV paper was published earlier than the FLG/AD paper(s). They also mention psoriasis in the patent application, but this disease has been proven not to be more common in FLG individuals. So, the patent is based onwhat they KNEW and were able to prove at that time, and it also holds some elements of speculation. Some of those speculations have been proven right (AD), and some have been proven wrong. (psoriasis).<br /><br />This is just a theory from my side...<br /><br />Regarding the use of aminoglycoside antibiotics: As far as I can see, the patent covers the use of any drug with read-through effect. I do believe that their intention is only to exhibit some early stage "proof of concept", and of course, they had to do this by using drugs avialable at that time. (Gentamicin, negamycin etc..)<br /><br /> Anonymousnoreply@blogger.com